基因名：
Rsad2
产品别名：
2510004L01Rik； Vig1； cig5； Rsad2； radical S-adenosyl methionine domain containing 2； radical S-adenosyl methionine domain containing 2； radical S-adenosyl methionine domain-containing protein 2； VHSV-induced-like protein； viperin； viral hemorrhagic septicemia virus (VHSV)-induced gene 1； virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible； 干扰素诱导内质网关联病毒抑制蛋白(Viperin)；
背景信息：
RSAD2 is a 361 amino acid protein that is involved in antiviral defense against pathogens such as Hep C, Cytomegalovirus and HIV-1. Localized to the cytosolic side of the endoplasmic reticulum and relocated to the Golgi apparatus upon viral infection, RSAD2 is thought to prevent viral budding by disrupting lipid rafts at the plasma membrane and supporting the Interferon-induced antiviral state of the cell. Additionally, RSAD2 can bind to and inactivate FDPS (an enzyme that is crucial for the synthesis of cholesterol and geranylated and farnesylated proteins), thereby playing a role in lipid synthesis. Overexpression of RSAD2 leads to abnormal lipid accumulation that is associated with atherosclerosis, a chronic inflammatory disease characterized by hardened arteries.
