基因名:
PPCDC
产品别名:
MDS018; PPC-DC; coaC; PPCDC; phosphopantothenoylcysteine decarboxylase; phosphopantothenoylcysteine decarboxylase; 磷酸泛酰半胱氨酸脱羧酶; 磷酸泛酰半胱氨酸脱羧酶(PPCDC);
背景信息:
Phosphopantothenoylcysteine Decarboxylase (PPC-DC) is an essential enzyme in the biosynthesis ofCoenzyme A and catalyzes the decarboxylation of PPC to Phosphopantetheine. PPC-DC catalyzes the decarboxylation of the Cysteine moiety of 4-Phosphopantothenoylcysteine (PPC) to form 4-Phosphopantetheine (PPantSH), this reaction forms part of the biosynthesis of Coenzyme A. The enzyme is a member of the larger family of Cysteine Decarboxylases including the Lantibiotic-Biosynthesizing enzymes EpiD and MrsD, all of which use a tightly bound Flavin cofactor to oxidize the Thiol moiety of the substrate to a Thioaldehyde.