基因名:
NIF3L1
产品别名:
ALS2CR1; CALS-7; MDS015; NIF3L1; NGG1 interacting factor 3 like 1; NGG1 interacting factor 3 like 1; NIF3-like protein 1; GTP cyclohydrolase I; NIF3 (Ngg1 interacting factor 3, S.pombe homolog)-like 1; NIF3 NGG1 interacting factor 3-like 1; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 1; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein; putative GTP cyclohydrolase 1 type 2 NIF3L1; 肌萎缩侧索硬化症相关蛋白1;
背景信息:
The NGG1 interacting factor 3-like 1 (NIF3L1) is a 377 amino acid protein expressed mainly in the cytoplasm of cells in several different tissues. It has been highly conserved throughout evolution, from bacteria to mammals. NIF3L participates in retinoic acid-primed neural differentiation of P19 embryonic carcinoma cells by cooperating with Trip15/CSN2, a transcriptional corepressor/component of COP9 signalosome. NIF3L1 interacts with itself and with the NIF3L1 binding protein 1 (NIF3L1 BP1), which is a novel protein presumed to contain a leucine zipper domain.