基因名：
Itm2c
产品别名：
3110038L02Rik； BRI3； Bricd2c； E25； E25C； ITM3； Itm2c； integral membrane protein 2C； integral membrane protein 2C； integral membrane protein 2C； integral membrane protein 3； transmembrane protein BRI3； 跨膜蛋白ITM2C；
背景信息：
Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
