基因名：
SMURF2
产品别名：
SMURF2； SMAD specific E3 ubiquitin protein ligase 2； SMAD specific E3 ubiquitin protein ligase 2； E3 ubiquitin-protein ligase SMURF2； E3 ubiquitin ligase SMURF2； HECT-type E3 ubiquitin transferase SMURF2； SMAD ubiquitination regulatory factor 2； hSMURF2； Smad蛋白E3泛素连接酶2；
背景信息：
SMURF2, a 748-amino acid ubiquitin E3 ligase that is 83% identical to SMURF1, codes for a C2-WW-HECT domain ubiquitin ligase that associates constitutively with SMAD7. Binding to SMAD7 induces export of SMURF2 and recruitment to the activated transforming growth factor-beta receptor (TGFBR), where it causes receptor and SMAD7 degradation. A strong interaction of second and third SMURF2 WW domains has been identified with SMAD1, SMAD2, and SMAD3, but not SMAD4. Western blot analysis showed that SMURF2 selectively downregulates the transcription of SMAD2 and SMAD1, but not SMAD3. The nuclear SMURF2/phosphorylated SMAD2 interaction is requires TGFB1.
