基因名：
WNK4
产品别名：
PHA2B； PRKWNK4； WNK4； WNK lysine deficient protein kinase 4； WNK lysine deficient protein kinase 4； serine/threonine-protein kinase WNK4； protein kinase lysine-deficient 4； protein kinase with no lysine 4；
背景信息：
Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+)channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+)secretion to maintain integrated homeostasis.
