基因名:
Pdgfd
产品别名:
Scdgfb; rSCDGF-B; Pdgfd; platelet derived growth factor D; platelet derived growth factor D; platelet-derived growth factor D; iris-expressed growth factor; platelet-derived growth factor, D polypeptide; spinal cord-derived growth factor B; spinal-cord derived growth factor-B protein; 血小板源性生长因子D/脊髓源性生长因子B; 血小板衍生生长因子D(PDGFD);
背景信息:
SCDGFB (Spinal cord derived growth factor B) is a member of the platelet derived growth factor family. It only forms homodimers and does not dimerize with the other three family members. It is a potent mitogen for cells of mesenchymal origin. It is activated by proteolytic cleavage and this active form acts as a specific ligand for beta platelet derived growth factor receptor. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. It induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis.