基因名：
Tab3
产品别名：
4921526G09Rik； Map3k7ip3； mKIAA4135； Tab3； TGF-beta activated kinase 1/MAP3K7 binding protein 3； TGF-beta activated kinase 1/MAP3K7 binding protein 3； TGF-beta-activated kinase 1 and MAP3K7-binding protein 3； TAK1-binding protein 3； TGF-beta-activated kinase 1-binding protein 3； mitogen-activated protein kinase kinase kinase 7-interacting protein 3； NFKB激活蛋白1；
背景信息：
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
