基因名：
Dusp26
产品别名：
2310043K02Rik； Skrp3； Dusp26； dual specificity phosphatase 26 (putative)； dual specificity phosphatase 26 (putative)； dual specificity protein phosphatase 26； dual-specificity phosphatase SKRP3； 双特异性磷酸酶26； 双特异性蛋白磷酸酶26；
背景信息：
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).
Tissue specificity:Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.
