基因名:
Nrarp
产品别名:
2700054M22Rik; Nrarp; Notch-regulated ankyrin repeat protein; Notch-regulated ankyrin repeat protein; notch-regulated ankyrin repeat-containing protein; Notch调控锚蛋白重复蛋白(NRARP); NOTCH调节锚蛋白;
背景信息:
Nrarp (NOTCH-regulated ankyrin repeat protein) is a 114 amino acid protein that contains two ANK repeats and is thought to play a role in the formation of somites. The gene encoding Nrarp maps to human chromosome 9, which contains 145 million base pairs and comprises 4% of the human genome, encoding nearly 900 genes. Hereditary hemorrhagic telangiectasia and Familial dysautonomia are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in translocations that lead to the aberrant production of a BCR-ABL fusion protein often found in leukemias.