基因名：
Cers4
产品别名：
2900019C14Rik； Lass4； Trh1； Cers4； ceramide synthase 4； ceramide synthase 4； ceramide synthase 4； LAG1 homolog, ceramide synthase 4； LAG1 longevity assurance homolog 4； TRAM homolog 1； longevity assurance homolog 4； sphingosine N-acyltransferase CERS4； translocating chain-associating membrane protein homolog 1； 长寿相关基因lASS4；
背景信息：
LASS4 is a member of the LASS (longevity assurance homologue) family which are involved in determining life span in yeast, by an unknown molecular mechanism. Members of this family are highly conserved from yeasts to mammals. Five mouse and human LASS family members, namely LASS1, LASS2, LASS4, LASS5 and LASS6, have been identified and characterized.
LASS proteins are thought to be involved in ceramide synthesis. Overproduction of a single LASS protein results in an increase in one or more specific ceramide species, which differ in fatty-acid chain length. LASS proteins possess specific fatty acyl-CoA preferences, but all can use sphingosine or dihydrosphingosine as the long-chain base substrate. LASS family members exhibit different tissue-specific expression patterns, which may contribute to the production of tissue-specific ceramides.
