基因名：
Akt1s1
产品别名：
1110012J22Rik； AI227026； Lobe； Lobel； PRAS40； Akt1s1； AKT1 substrate 1 (proline-rich)； AKT1 substrate 1 (proline-rich)； proline-rich AKT1 substrate 1； proline-rich AKT substrate； 磷酸化蛋白激酶AKT底物1； 蛋白激酶AKT底物1；
背景信息：
Proline Rich Akt Substrate (PRAS40) is a 40 kDa substrate of Akt. Akt and PRAS40 can be found in the phosphoinositide 3 kinase (PI3K) pathway, which plays a role in glucose uptake, cell growth, and apoptosis inhibition. PRAS40 is a 14-3-3 binding protein that reacts with insulin, but whose precise function is not yet known. It may bind SH3 and WW domain containing proteins resulting in a change of function. Activated Akt phosphorylates PRAS40 on threonine 246. Mutation of PRAS40 threonine 246 has been shown to be apoptotic.
