基因名：
Ube2f
产品别名：
2510010F15Rik； AI851109； Ube2f； ubiquitin-conjugating enzyme E2F (putative)； ubiquitin-conjugating enzyme E2F (putative)； NEDD8-conjugating enzyme UBE2F； NEDD8 carrier protein UBE2F； NEDD8 protein ligase UBE2F； NEDD8-conjugating enzyme 2； RING-type E3 NEDD8 transferase UBE2F； ubiquitin-conjugating enzyme E2 F； 泛素结合酶E2C结合蛋白E2F(UBE2F)；
背景信息：
Ube2F is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for conjugation of Nedd8 to protein substrates. Neddylation is initiated by activating Nedd8 by the Nedd8 activating enzyme APPBP1/UBA3. Cullin is a well-known substrate for Neddylation. When NEDD8 is covalently bonded to the CRL, it stimulates its E3 Ub ligase activity. A new approach to cancer therapy involves hindering the Nedd8 conjugation pathway through inhibition of the NAE1/UBA3 enzyme.
