基因名：
Kmt5a
产品别名：
2410195B05Rik； AA617402； AW536475； PR-SET7； PR/SET07； Setd8； Kmt5a； lysine methyltransferase 5A； lysine methyltransferase 5A； N-lysine methyltransferase KMT5A； H4-K20-HMTase KMT5A； H4-K20-HMTase SETD8； N-lysine methyltransferase SETD8； PR/SET domain-containing protein 07； SET domain containing (lysine methyltransferase) 8； SET domain-containing protein 8； histone-lysine N-methyltransferase KMT5A； histone-lysine N-methyltransferase SETD8； lysine-specific methylase 5A； 组蛋白H4 K20甲基转移酶；
背景信息：
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes.
