基因名：
Ppp1r14a
产品别名：
1110001M11Rik； CPI-17； Cpi17； Ppp1r14a； protein phosphatase 1, regulatory inhibitor subunit 14A； protein phosphatase 1, regulatory inhibitor subunit 14A； protein phosphatase 1 regulatory subunit 14A； 17 kDa PKC-potentiated inhibitory protein of PP1； protein kinase C-potentiated inhibitor protein of 17 kDa； 磷酸化蛋白磷酸激酶PKC/CPI-17； 蛋白磷酸激酶PKC/CPI-17；
背景信息：
Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated, PPP1R14A has over 1000-fold higher inhibitory activity, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. In addition, inhibition of PPP1R14A also enhances contraction of smooth muscle in the absence of increment of intracellular Ca2+ concentration.
