基因名：
Aspscr1
产品别名：
1190006K01Rik； ASPC； ASPCR1； ASPL； ASPS； RCC17； TUG； Aspscr1； alveolar soft part sarcoma chromosome region, candidate 1 (human)； alveolar soft part sarcoma chromosome region, candidate 1 (human)； tether containing UBX domain for GLUT4； alveolar soft part sarcoma chromosomal region candidate gene 1 protein homolog； tether, containing a UBX domain, for GLUT4； 腺泡状软组织肉瘤结构域蛋白ASPC；
背景信息：
Glut4 is a twelve pass transmembrane protein (12TM) whose carboxy-terminus may dictate its cellular localization. Aberrant Glut4 expression has been suggested to contribute to such maladies as obesity and diabetes. Glut4 null mice have shown that while functional Glut4 protein is not required for maintaining normal glucose levels, it is necessary for sustained growth, normal cellular glucose, fat metabolism and prolonged longevity. TUG (ASPL in humans) regulates the trafficking of glucose via Glut4. Full-length TUG forms a complex with Glut4 and in 3T3-L1 adipocytes and this complex is present in unstimulated cells and is disassembled by insulin. TUG acts by trapping endocytosed Glut4 and tethering it intracellularly. Insulin mobilizes this pool of retained Glut4 by releasing the tether.
