基因名：
Abraxas1
产品别名：
3830405G04Rik； 5630400M01Rik； AI506069； AL024423； AV118690； Ccdc98； Fam175a； Abraxas1； BRCA1 A complex subunit； BRCA1 A complex subunit； BRCA1-A complex subunit Abraxas 1； coiled-coil domain containing 98； coiled-coil domain-containing protein 98； family with sequence similarity 175, member A； 卷曲螺旋结构域蛋白98；
背景信息：
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
