基因名：
Sting1
产品别名：
2610307O08Rik； ERIS； MPYS； Mita； STING； STING-beta； Tmem173； Sting1； stimulator of interferon response cGAMP interactor 1； stimulator of interferon response cGAMP interactor 1； stimulator of interferon genes protein； endoplasmic reticulum interferon stimulator； mediator of IRF3 activation； mitochondrial mediator of IRF3 activation； stimulator of interferon protein； transmembrane protein 173； 跨膜蛋白173； 跨膜蛋白173(TMEM173)；
背景信息：
Stimulator of Interferon Gene(Sting,TMEM173) belongs to the TMEM173 family. STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a C-terminal cytoplasmic domain (aa 174-379). It ubiquitously expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophagesand. Its subunit structure associated with the MHC-II complex and Interacts with DDX58/RIG-I, MAVS and SSR2, RNF5 and TRIM56 along with TBK1. This type of protein often uses as facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon.
