基因名：
Bmper
产品别名：
3110056H04Rik； CV-2； Crim3； Cv2； Bmper； BMP-binding endothelial regulator； BMP-binding endothelial regulator； BMP-binding endothelial regulator protein； bone morphogenetic protein-binding endothelial cell precursor-derived regulator； crossveinless-2； BMP内皮细胞调节蛋白； BMP结合内皮调节因子(BMPER)；
背景信息：
This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. [provided by RefSeq, Dec 2011].
BMPER is a BMP-binding protein that is expressed by endothelial cell precursors, has BMP-antagonizing activity, and may play a role in endothelial cell differentiation by modulating local BMP activity. It may also regulate BMP responsiveness in osteoblasts and chondrocytes.
