基因名：
Setd7
产品别名：
1600028F23Rik； H3K4MT； KMT7； Set7； Set7/9； mKIAA1717； Setd7； SET domain containing (lysine methyltransferase) 7； SET domain containing (lysine methyltransferase) 7； histone-lysine N-methyltransferase SETD7； H3-K4 methyltransferase； H3-K4-HMTase SETD7； SET domain-containing protein 7； histone H3-K4 methyltransferase SETD7； 含SET域蛋白7(SETD7)； 组蛋白H4-K4甲基转移酶；
背景信息：
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.
