基因名：
Crtc2
产品别名：
4632407F12Rik； Torc2； Crtc2； CREB regulated transcription coactivator 2； CREB regulated transcription coactivator 2； CREB-regulated transcription coactivator 2； TORC-2； transducer of CREB protein 2； transducer of regulated cAMP response element-binding protein 2； CREB调控转录辅激活因子2(CRTC2)； CREB转录共激活因子TORC2； 磷酸化CREB转录共激活因子TORC2；
背景信息：
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010].
