基因名：
TRPM8
产品别名：
LTRPC6； LTrpC-6； TRPP8； trp-p8； TRPM8； transient receptor potential cation channel subfamily M member 8； transient receptor potential cation channel subfamily M member 8； transient receptor potential cation channel subfamily M member 8； TRPM8 cationic channel； transient receptor potential p8； transient receptor potential subfamily M member 8； “冷”蛋白TRPM8； 转化受体电位阳离子通道亚家族M成员8(TRPM8)；
背景信息：
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
