基因名：
DHX58
产品别名：
D11LGP2； D11lgp2e； LGP2； RLR-3； DHX58； DExH-box helicase 58； DExH-box helicase 58； ATP-dependent RNA helicase DHX58； probable ATP-dependent RNA helicase DHX58； ATP-dependent helicase LGP2； DEXH (Asp-Glu-X-His) box polypeptide 58； RIG-I-like receptor 3； RIG-I-like receptor LGP2； RLR； RNA helicase LGP2； ortholog of mouse D11lgp2； probable ATP-dependent helicase LGP2； protein D11Lgp2 homolog； DHX58蛋白；
背景信息：
DHX58, is a 678 amino acid protein belonging to the helicase family. LGP2 acts as a negative regulator of host innate immune defense against viruses by binding dsRNA produced during viral replication. The repressor domain of LGP2 binds to RIG-I, a signaling protein involved in host defenses against hepatitis C virus (HCV). By preventing RIG-I multimerization, LGP2 negatively regulates RIG-I-mediated signaling. Localized to the cytoplasm, LGP2 contains one helicase ATP-binding domain and one helicase C-terminal domain.
