基因名：
TNIP2
产品别名：
ABIN2； FLIP1； KLIP； TNIP2； TNFAIP3 interacting protein 2； TNFAIP3 interacting protein 2； TNFAIP3-interacting protein 2； A20-binding inhibitor of NF-kappaB activation-2； fetal liver LKB1-interacting protein； 肿瘤坏死因子α诱导蛋白32； 肿瘤坏死因子α诱导蛋白3相互作用蛋白2(TNIP2)；
背景信息：
The human TNIP2 (also known as ABIN-2), which is related to proteins ABIN-1 and ABIN-3, was originally identified as an A20-associating cytosolic protein that block nuclear factor kappaB (NF-kB) activation. NF-kB plays a central role in the regulation of genes implicated in immune responses, inflammatory processes, and apoptotic cell death and the zinc finger protein A20 is a potent inhibitor of NF-kB activity with a key role in limiting the extent and duration of inflammatory activation. It was also reported that ABIN-2 has the potential to enter the nucleus and plays a role in mediating transcriptional activation in both yeast and mammalian cells.
