基因名:
TBL1XR1
产品别名:
C21; DC42; IRA1; MRD41; TBLR1; TBL1XR1; TBL1X/Y related 1; TBL1X/Y related 1; F-box-like/WD repeat-containing protein TBL1XR1; TBL1-related protein 1; TBL1X receptor 1; nuclear receptor co-repressor/HDAC3 complex subunit; nuclear receptor corepressor/HDAC3 complex subunit TBLR1; transducin beta like 1 X-linked receptor 1; 转导素β1X连锁受体蛋白1;
背景信息:
TBLR1 is an F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. It plays an essential role in transcription activation mediated by nuclear receptors and probably acts as an integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of the N-Cor complex, thereby allowing cofactor exchange, and transcription activation.