基因名：
Hcar2
产品别名：
Gpr109a； Gpr109b； HM74； Niacr1； PUMA-G； Pumag； mHM74b； Hcar2； hydroxycarboxylic acid receptor 2； hydroxycarboxylic acid receptor 2； hydroxycarboxylic acid receptor 2； G protein-coupled receptor 109A； G protein-coupled receptor 109B； G-protein coupled receptor 109； G-protein coupled receptor HM74； interferon-gamma inducible gene, Puma-g； niacin receptor 1； nicotinic acid receptor； putative seven transmembrane spanning receptor； G蛋白偶联受体109A；
背景信息：
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis.
