基因名：
ADAMTS10
产品别名：
ADAM-TS10； ADAMTS-10； WMS； WMS1； ADAMTS10； ADAM metallopeptidase with thrombospondin type 1 motif 10； ADAM metallopeptidase with thrombospondin type 1 motif 10； A disintegrin and metalloproteinase with thrombospondin motifs 10； ADAM-TS 10； a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10； zinc metalloendopeptidase； 整合素样金属蛋白酶与凝血酶10型； 血小板反应蛋白解整合素金属肽酶10(ADAMTS10)；
背景信息：
ADAMTS10 is a member of the ADAMs family of proteinases with Thrombospondin motifs. The catalytic site of ADAMTS10 is typical of the metalloproteinase catalytic domains, with an HExxHxxxxxH sequence, perhaps giving these enzymes some shared specificity. ADAMTS10 is closest in homology to ADAMTS6, sharing 53% overall identity. Functional mutations in ADAMTS10 have been linked to Weill Marchesani syndrome, a connective tissue disorder marked by fibrillin 1 misprocessing. ADAMTS10 has also been reported to be over expressed in breast cancer tissues and cell lines.
