基因名:
TRAF7
产品别名:
CAFDADD; RFWD1; RNF119; TRAF7; TNF receptor associated factor 7; TNF receptor associated factor 7; E3 ubiquitin-protein ligase TRAF7; RING finger and WD repeat-containing protein 1; RING finger protein 119; RING-type E3 ubiquitin transferase TRAF7; TNF receptor-associated factor 7, E3 ubiquitin protein ligase; ring finger and WD repeat domain 1; 肿瘤坏死因子受体相关因子7;
背景信息:
TNF receptor associated factor 7 (TRAF7) is an E3 ubiquitin ligase capable of auto ubiquination, following phosphorylation by MAP3K3. TRAF7 potentiates MEKK3 mediated activation of the NFkappaB, JUN/AP1 and DDIT3 transcriptional regulators. TRAF7 induces apoptosis when over expressed.