基因名：
HAVCR2
产品别名：
CD366； HAVcr-2； KIM-3； SPTCL； TIM3； TIMD-3； TIMD3； Tim-3； HAVCR2； hepatitis A virus cellular receptor 2； hepatitis A virus cellular receptor 2； hepatitis A virus cellular receptor 2； T cell immunoglobulin mucin 3； T-cell immunoglobulin and mucin domain 3； T-cell immunoglobulin and mucin domain-containing protein 3； T-cell immunoglobulin mucin family member 3； T-cell immunoglobulin mucin receptor 3； T-cell membrane protein 3； kidney injury molecule-3； TIM-3蛋白； T淋巴细胞膜蛋白3； 甲型肝炎病毒细胞受体2(HAVCR2)； 甲型肝炎病毒细胞受体2(HAVCR2)真核蛋白；
背景信息：
Hepatitis A virus cellular receptor 2（HAVCR2）is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
