基因名:
RELT
产品别名:
AI3C; TNFRSF19L; TRLT; RELT; RELT TNF receptor; RELT TNF receptor; tumor necrosis factor receptor superfamily member 19L; RELT tumor necrosis factor receptor; receptor expressed in lymphoid tissues; 肿瘤坏死因子受体超家族成员19L; 肿瘤坏死因子受体超家族成员19样蛋白(TNFRSF19L);
背景信息:
Tumor necrosis factor receptor superfamily member 19L (TNFRSF19L), also known as Receptor expressed in lymphoid tissues and RELT, is a member of the TNF-receptor superfamily. TNFRSF19L is a single-pass type membrane protein and contains one TNFR-Cys repeat. TNFRSF19L is highly expressed in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow and fetal liver. It has been shown TNFRSF19L activates the NF-kappaB pathway and selectively binds TNF receptor-associated factor 1 (TRAF1). TNFRSF19L is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response.