基因名：
TRIM5
产品别名：
RNF88； TRIM5alpha； TRIM5； tripartite motif containing 5； tripartite motif containing 5； tripartite motif-containing protein 5； RING-type E3 ubiquitin transferase TRIM5； ring finger protein 88； tripartite motif protein TRIM5； 含三联基元蛋白5(TRIM5)； 环指蛋白88；
背景信息：
Tripartite motif-containing Motif 5 is a protein that in humans is encoded by the TRIM5 gene.It is a 493 amino acids protein that belongs to the TRIM/RBCC family.It contains 1 B box-type zinc finger, 1 B30.2/SPRY domain and 1 RING-type zinc finger. TRIM5 present in the cytoplasm recognizes motifs within the capsid proteins and interferes with the uncoating process, therefore preventing successful reverse transcription and transport to the nucleus of the viral genome. The exact mechanism of action has not been shown conclusively, but capsid protein from restricted viruses is removed by proteasome-dependent degradation
