基因名:
NAV1
产品别名:
POMFIL3; STEERIN1; UNC53H1; NAV1; neuron navigator 1; neuron navigator 1; neuron navigator 1; pore membrane and/or filament interacting like protein 3; unc-53 homolog 1; 神经细胞引领蛋白Nav1;
背景信息:
Neuron navigator 1 is a 1877 amino acid cytoplasmic protein that is involved in neuronal migration. Neuron navigtor 1 is widely expressed at low levels, though highest expression is found in both adult and fetal nervous tissue. Through interaction with tubulin, Neuron navigator 1 associates with a subset of mirotubule plus ends present in the growth cone. Overexpression of Neuron navigator 1 leads to microtubule bundling, whereas a reduction of its levels causes loss of directionality in the migration of pontine cell leading processes. There are seven isoforms of Neuron navigator 1 that are produced as a result of alternative splicing events.