基因名：
LRSAM1
产品别名：
CMT2P； RIFLE； TAL； LRSAM1； leucine rich repeat and sterile alpha motif containing 1； leucine rich repeat and sterile alpha motif containing 1； E3 ubiquitin-protein ligase LRSAM1； RING finger leucine repeat rich； RING-type E3 ubiquitin transferase LRSAM1； Tsg101-associated ligase； LRSAM1蛋白；
背景信息：
LRSAM1 is an E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivation of the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. It selectively regulates cell adhesion molecules and plays a role in receptor endocytosis and viral budding. LRSAM1 contains a RING-type zinc finger, 5 leucine-rich repeats and 1 SAM (sterile alpha motif) domain. The coiled coil domains interact with the SB domain of TSG101. The PTAP motifs mediate the binding to UEV domains. There are 3 isoforms produced by alternative splicing.
