基因名：
Pcsk9
产品别名：
AI415265； AI747682； FH3； HCHOLA3； Narc1； PC9； Pcsk9； proprotein convertase subtilisin/kexin type 9； proprotein convertase subtilisin/kexin type 9； proprotein convertase subtilisin/kexin type 9； NARC-1； convertase subtilisin； neural apoptosis regulated convertase 1； proprotein convertase 9； proprotein convertase PC9； subtilisin/kexin-like protease PC9； 前蛋白转化酶枯草溶菌素9(PCSK9)； 神经细胞凋亡调节转化蛋白1/前蛋白转化酶枯草溶菌素9；
背景信息：
Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.
