基因名：
Nlrp6
产品别名：
AI504961； Avr； Nalp6； Navr； Navr/Avr； Non-AVR； Pypaf5； Nlrp6； NLR family, pyrin domain containing 6； NLR family, pyrin domain containing 6； NACHT, LRR and PYD domains-containing protein 6； NACHT, leucine rich repeat and PYD containing 6； NACHT/LRR/pyrin domain-containing protein 6； PYRIN-containing APAF1-like protein 5； angiotensin II/vasopressin receptor； non-angiotensin-vasopressin receptor； 富含亮氨酸重复结构域蛋白6；
背景信息：
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]
