基因名：
EGLN2
产品别名：
EIT-6； EIT6； HIF-PH1； HIFPH1； HPH-1； HPH-3； PHD1； EGLN2； egl-9 family hypoxia inducible factor 2； egl-9 family hypoxia inducible factor 2； prolyl hydroxylase EGLN2； HIF-prolyl hydroxylase 1； egl nine homolog 2； estrogen-induced tag 6； hypoxia-inducible factor prolyl hydroxylase 1； prolyl hydroxylase domain-containing protein 1； 脯氨酰羟化酶；
背景信息：
PHD1 catalyzes the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins and hydroxylates HIF-1 alpha at Pro-402 and Pro-564, and HIF-2 alpha. It functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. It may play a role in cell growth regulation.
