基因名：
TP53RK
产品别名：
BUD32； C20orf64； GAMOS4； Nori-2； Nori-2p； PRPK； TPRKB； dJ101A2； TP53RK； TP53 regulating kinase； TP53 regulating kinase； EKC/KEOPS complex subunit TP53RK； atypical serine/threonine protein kinase TP53RK； p53-related protein kinase； TP53调节激酶；
背景信息：
PRPK is a 253 amino acid protein kinase that phosphorylates Ser15 of p53. PRPK phosphorylation of p53 causes increased stabilization and activity of p53. CGI-121 may act as an inhibitor of the PRPK-p53 interaction, thus preventing the phosphorylation of p53. Unphosphorylated p53 is degraded by the ubiquitin-proteasome pathway, which may ultimately lead to cell proliferation. PRPK contains a protein kinase domain with a conserved catalytic core. PRPK is localized to the nucleus of the cell and is highly expressed in testis, with lower expression in heart, kidney and spleen.
