基因名：
mafa
产品别名：
Z-cmaf； c-Maf； fl13d12； maf； wu:fl13d12； mafa； v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a)； v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a)； transcription factor Maf； proto-oncogene c-maf； v-maf musculoaponeurotic fibrosarcoma oncogene homolog； v-maf肌腱膜纤维肉瘤癌基因同源物A；
背景信息：
Insulin gene expression is regulated by several islet-enriched transcription factors. However, MAFA is the only beta cell-specific activator. MAFA selectively induces endogenous insulin transcription in non-beta cells. MAFA was also first detected in the insulin-producing cells formed during the second and predominant phase of beta cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta cells. These results demonstrate that MAFA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development.
