基因名：
TIRAP
产品别名：
BACTS1； Mal； MyD88-2； wyatt； TIRAP； TIR domain containing adaptor protein； TIR domain containing adaptor protein； toll/interleukin-1 receptor domain-containing adapter protein； MyD88 adapter-like protein； Toll-like receptor adaptor protein； adapter protein wyatt； adaptor protein Wyatt； toll-interleukin 1 receptor (TIR) domain containing adaptor protein； 含Toll白介素1受体域衔接蛋白(TIRAP)； 白细胞介素1受体衔接蛋白； 磷酸化白细胞介素1受体衔接蛋白；
背景信息：
The Toll-like receptor (TLR) family in mammals comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. TIRAP (TIR domain-containing adaptor protein) is an adaptor protein used by TLR4. Blocking TIRAP inhibits TLR4-mediated signaling events, including DC maturation and cytokine production.
