基因名：
IL22RA2
产品别名：
CRF2-10； CRF2-S1； CRF2X； IL-22BP； IL-22R-alpha-2； IL-22RA2； ZCYTOR16； IL22RA2； interleukin 22 receptor subunit alpha 2； interleukin 22 receptor subunit alpha 2； interleukin-22 receptor subunit alpha-2； cytokine receptor class-II member 10； cytokine receptor family type 2, soluble 1； interleukin 22 receptor, alpha 2； interleukin 22-binding protein； 白介素22受体α2(IL22Ra2)； 白介素22受体结合蛋白；
背景信息：
Interleukin 22 binding protein (IL-22BP), also known as CRF2-10, CRF2-X, and IL-22RA2, is a 35-45 kDa secreted glycoprotein in the type II cytokine receptor family (CRF). IL-22BP specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor.IL-22BP is produced by dendritic cells (DC), epithelial cells, activated B cells, and activated monocytes. It is constitutively expressed by DC but is down-regulated during local inflammation and in response to tissue damage. IL-22BP is critical for limiting IL-22 induced epithelial cell proliferation during wound healing, and its deficiency can enable uncontrolled proliferation and enhance tumor development.
