基因名：
Cntn4
产品别名：
Axcam； Big-2； Cntn4； contactin 4； contactin 4； contactin-4； axonal-associated cell adhesion molecule； brain-derived immunoglobulin superfamily protein 2； 接触蛋白4(CNTN4)； 轴突相关粘附分子；
背景信息：
Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination. Tissue specificity: Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord. Similarity: Belongs to the immunoglobulin superfamily. Contactin family. Contains 4 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
