GPR62 is a 368 amino acid protein encoded by the human GPR62 gene. GPR62 is an orphan receptor member of the G protein-coupled receptor 1 family. G protein-coupled receptors (GPCRs or GPRs) contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. Key roles for G protein-coupled receptors include control of protein maturation and cell surface delivery and providing the correct framework for interactions with both heterotrimeric G proteins and arrestins to allow signal generation and its termination. GPR62 is expressed in brain tissue, most notably the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus.