基因名：
HSPB6
产品别名：
HEL55； Hsp20； PPP1R91； HSPB6； heat shock protein family B (small) member 6； heat shock protein family B (small) member 6； heat shock protein beta-6； epididymis luminal protein 55； epididymis secretory sperm binding protein； heat shock 20 kDa-like protein p20； heat shock protein family B (small) member B6； heat shock protein, alpha-crystallin-related, B6； protein phosphatase 1, regulatory subunit 91； 热休克蛋白-20； 热休克蛋白β6(HSPb6)；
背景信息：
Hsp20 is a small heat shock protein related to Hsp25, Hsp27 and may form different hetercomplexes with these proteins. The specific physiological function of Hsp20 is not yet known. It is distributed ubiquitously in tissues, but is found in higher levels in skeletal, smooth and heart muscle. Under normal conditions, Hsp20 is diffusely distributed in the cytosol, but under heat stress conditions, it translocates to the nucleus. Unlike other heat shock proteins the amount of Hsp20 does not increase after heat shock. The Hsp20 was demonstrated to constitute up to 1.3% of the total cellular protein in vertebrate tissues, especially in muscle, and its expression is related to muscle contraction, specifically in slow-twitch muscle. Hsp20 may form different heterocomplexes with other Hsp's, such as alpha-crystalline and Hsp25. Phosphorylated form of Hsp20 is proposed to interact with monomeric actin whereas dephosphorylated form binds polymeric actin filaments. In normal conditions Hsp20 is diffusely disturbed in cytosol but under the heat stress it undergoes translocation to membrane fraction.
