基因名：
CD109
产品别名：
CPAMD7； p180； r150； CD109； CD109 molecule； CD109 molecule； CD109 antigen； 150 kDa TGF-beta-1-binding protein； C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7； Gov platelet alloantigens； activated T-cell marker CD109； platelet-specific Gov antigen； CD109分子(CD109)； 转化生长因子β1结合蛋白；
背景信息：
CD109 is a a novel member of the alpha2-macroglobulin (alpha2M)/complement superfamily. It is a glycosylphosphatidylinositol (GPI)-linked cell surface glycoprotein of approximately 170 kd found on endothelial cells, activated platelets and T-cells and on a subset of hematopoietic stem and progenitor cells. Although it has been suggested that T-cell CD109 may play a role in antibody-inducing T-helper function and it is known that platelet CD109 carries the Gov alloantigen system, the role of CD109 in hematopoietic cells remains largely unknown. CD109 has been identified as part of the TGF-beta receptor system in human keratinocytes and upregulation of CD109 expression has been observed in several different types of tumour.
