基因名：
DENND1B
产品别名：
C1ORF18； C1orf218； FAM31B； DENND1B； DENN domain containing 1B； DENN domain containing 1B； DENN domain-containing protein 1B； DENN/MADD domain containing 1B； connecdenn 2； family with sequence similarity 31, member B； DENND1B蛋白；
背景信息：
Guanine nucleotide exchange factor (GEF) for RAB35. May function as a clathrin-associated sorting protein for RAB35, whereby during clathrin-mediated endocytosis, binds the AP-2 complex and inactived RAB35, then activates RAB35 for its subsequent function at endosomes.
Tissue specificity:Highly expressed in dendritic and natural killer cells and at lower levels in other myeloid lineage cells and in pituitary. Significantly up-regulated in effector memory T cells as compared with naive T cells.
