基因名：
IFNLR1
产品别名：
CRF2/12； IFNLR； IL-28R1； IL28RA； LICR2； IFNLR1； interferon lambda receptor 1； interferon lambda receptor 1； interferon lambda receptor 1； CRF2-12； IFN-lambda receptor 1； IFN-lambda-R1； IL-28 receptor subunit alpha； IL-28R-alpha； IL-28RA； class II cytokine receptor CRF2/12； cytokine receptor class-II member 12； cytokine receptor family 2 member 12； interleukin 28 alpha receptor； interleukin 28 receptor A； interleukin 28 receptor, alpha (interferon, lambda receptor)； interleukin or cytokine receptor 2； interleukin-28 receptor subunit alpha； likely interleukin or cytokine receptor 2； 白细胞介素28受体； 白细胞介素28受体α；
背景信息：
IL-28R is a 535 amino acid protein encoded by the human gene IL28RA. IL-28R belongs to the type II cytokine receptor family and contains 1 fibronectin type-III domain. It is a single-pass type I membrane protein found as a heterodimer with IL-10RB. This is a receptor for a small family of structurally-related cytokines that, like IFNs, are known to induce antiviral activity. The expression of IFN-I (IL-28) mRNA is inducible by viral infection in several cell lines. The receptor complex (IL-28R) that is utilized by all three IFN-l proteins for signaling is composed of two subunits, a receptor designated IL-28R and IL-10R2. Both receptor chains are constitutively expressed on a wide variety of human cell lines and tissues and signal through the Jak-STAT (Janus kinases-signal transducers and activators of transcription) pathway.
