基因名：
Rspo1
产品别名：
R-spondin； Rspondin； Rspo1； R-spondin 1； R-spondin 1； R-spondin-1； R-spondin homolog； cristin-3； cysteine-rich and single thrombospondin domain-containing protein 3； mCristin-3； roof plate-specific spondin-1； thrombospondin type 1 domain containing gene Rspondin； R-脊椎蛋白1(RSPO1)； RSPO1蛋白； 分泌性蛋白RSPO1；
背景信息：
RSPO1 is a secreted protein,containing 2 FU(furin-like) repeats and 1 TSP type-1 domain and belonging to the R-spondin family. RSPO1 is required for the early development of gonads, regardless of sex. It has been found in mice only eleven days after fertilization. To induce cell proliferation, it acts synergistically with WNT4. They help stabilize β catenin, which activates downstream targets. RSPO1 is necessary in female sex development. It augments the WNT/β catenin pathway to oppose male sex development. In critical gonadal stages, between six and nine weeks after fertilization, the ovaries upregulate it while the testes downregulate it. RSPO1 can potentially aid in the treatment of mucositis, which is characterized by inflammation of the oral cavity. This unfortunate condition often accompanies chemotherapy and radiation in cancer patients with head and neck tumors.
