重组Ig和ITIM域蛋白T-细胞免疫受体(TIGIT)

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重组Ig和ITIM域蛋白T-细胞免疫受体(TIGIT)真核蛋白
Recombinant TIGIT

基因名：

TIGIT

产品别名：

VSIG9； VSTM3； WUCAM； TIGIT； T cell immunoreceptor with Ig and ITIM domains； T cell immunoreceptor with Ig and ITIM domains； T-cell immunoreceptor with Ig and ITIM domains； V-set and immunoglobulin domain containing 9； V-set and immunoglobulin domain-containing protein 9； V-set and transmembrane domain containing 3； V-set and transmembrane domain-containing protein 3； VSIG9, VSTM3； Washington University cell adhesion molecule； Ig和ITIM域蛋白T-细胞免疫受体(TIGIT)； Ig和ITIM域蛋白T-细胞免疫受体(TIGIT)真核蛋白； TIGIT蛋白；

背景信息：

T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the CD28 family within the Ig superfamily of proteins. TIGIT is expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155 and Nectin-2 that appear on dendritic cells (DC) and endothelium. Ligation of TIGIT on T cells down-regulates TCR-mediated activation and subsequent proliferation, while NK cell TIGIT ligation blocks NK cell cytotoxicity. Through CD155 and Nectin-2, which also interact with DNAM-1/CD226 and CD96/Tactile, TIGIT is part of an interacting network of Ig superfamily members that may augment or oppose each other. In particular, TIGIT binding to CD155 can antagonize the effects of DNAM1.

标签：His-tag
分类：Recombinant
类型：Protein
偶联物：Unconjugated
内毒素水平：按批次，参阅瓶身标签
性状:Liquid
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型：purified
内含物：不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存：2-8°C不超过一个月，-80°C不超过12个月。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。