基因名:
NEIL2
产品别名:
NEH2; NEI2; NEIL2; nei like DNA glycosylase 2; nei like DNA glycosylase 2; endonuclease 8-like 2; DNA glycosylase/AP lyase Neil2; DNA-(apurinic or apyrimidinic site) lyase Neil2; nei endonuclease VIII-like 2; nei homolog 2; nei-like protein 2; 核酸内切酶8样蛋白2;
背景信息:
NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])[supplied by OMIM, Mar 2008]