基因名：
FNDC5
产品别名：
FRCP2； irisin； FNDC5； fibronectin type III domain containing 5； fibronectin type III domain containing 5； fibronectin type III domain-containing protein 5； fibronectin type III repeat-containing protein 2； Ⅲ型纤维连接蛋白域蛋白2/5； 含Ⅲ型纤连蛋白域蛋白5(FNDC5)； 含Ⅲ型纤连蛋白域蛋白5(FNDC5)真核蛋白；
背景信息：
Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene.Human Irisin is synthesized as a 212 amino acid (aa) precursor encoding a type 1 transmembrane protein with a 121 aa extracellular domain (ECD), a 21 aa transmembrane domain, and a 39 aa cytoplasmic domain. The ECD of Irisin contains a fibronectin type III domain and multiple glycosylation sites. The ECD is proteolytically cleaved to release the 112 aa soluble Irisin hormone into circulation.Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts.
